PUBLICATIONS

Publications in refereed scientific journals [all partners]

X.H. Wang, H.C. Schröder, U. Schloßmacher, L. Jiang, M. Korzhev and W.E.G. Müller: Biosilica aging: From enzyme-driven gelation via syneresis to chemical/biochemical hardening. Biochim.Biophys. Acta 1830, 3437-3446 (2013).

W.E.G. Müller, E. Mugnaioli, H.C. Schröder, U. Schloßmacher, M. Giovine, U. Kolb and X.H. Wang: Hierarchical composition of the axial filament from spicules of the siliceous sponge Suberites domuncula: From biosilica-synthesizing nanofibrils to structure- and morphology-guiding triangular stems. Cell Tissue Res. 351, 49-58 (2013).

X.H. Wang, H.C. Schröder, Q.L. Feng, F. Draenert and W.E.G. Müller: The deep-sea natural products, biogenic polyphosphate (bio-polyP) and biogenic silica (bio-silica) as biomimetic scaffolds for bone tissue engineering: Fabrication of a morphogenetically-active polymer. Mar. Drugs 11, 718-746 (2013).

T. Link, X.H. Wang, U. Schloßmacher, Q.L. Feng, H.C. Schröder and Werner E.G. Müller: An approach to a biomimetic bone scaffold: increased expression of BMP-2 and of osteoprotegerin in SaOS-2 cells grown onto silica-biologized 3D printed scaffolds. RSC Adv. 3, 11140-11147 (2013).

W.E.G. Müller, H.C. Schröder, D. Pisignano, J. Markl and X.H. Wang: Metazoan Circadian Rhythm: Toward an understanding of a light-based zeitgeber in sponges. Integr. Comp. Biol. 53, 103-117 (2013).

U. Schloßmacher, H.C. Schröder, X.H. Wang, Q.L. Feng, B. Diehl-Seifert, S. Neumann, A. Trautwein and W.E.G. Müller: Alginate/silica composite hydrogel as a potential morphogenetically active scaffold for three-dimensional tissue engineering. RSC Adv. 3, 11185-11194 (2013).

X.H. Wang, L. Gan, H.C. Schröder and W.E.G. Müller: Paradigm shift in bioinorganic chemistry: Enzymatic polycondensation reaction of silica in siliceous sponges. Prog. Chem. 25, 435-445 (2013).

W.E.G. Müller, L. Qiang, H.C. Schröder, N. Hönig, D. Yuan, V.A. Grebenjuk, F. Mussino, M. Giovine, H.C. Schröder and X.H. Wang: Carbonic anhydrase: A key regulatory and detoxifying enzyme for Karst plants. Planta 239, 213-229 (2014).

W.E.G. Müller, X.H. Wang, V. Grebenjuk, B. Diehl-Seifert, R. Steffen, U. Schloßmacher, A. Trautwein, S. Neumann and H.C. Schröder: Silica as a morphogenetically active inorganic polymer. Biomater. Sci. 1, 669-678 (2013).

W.E.G. Müller, H.C. Schröder, Q.L. Feng, U. Schlossmacher, T. Link and X.H. Wang: Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica-alginate hydrogel for SaOS-2 cell cultivation. J. Tissue Eng. Regen. Med. 9, E39-50 (2015).

W.E.G. Müller, U. Schlossmacher, H.C. Schröder, I. Lieberwirth, G. Glasser, M. Korzhev, M. Neufurth and X.H. Wang: Enzyme-accelerated and structure-guided crystallization of calcium carbonate: Role of the carbonic anhydrase in the homologous system. Acta Biomater. 10, 450-462 (2014).

W.E.G. Müller, H.C. Schröder, U. Schlossmacher, V.A. Grebenjuk, H. Ushijima and X.H. Wang: Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation. Biomaterials 34, 8671-8680 (2013).

W.E.G. Müller, H.C. Schröder, U. Schlossmacher, M. Neufurth, W. Geurtsen, M. Korzhev and X.H. Wang: The enzyme carbonic anhydrase as an integral component of biogenic Ca-carbonate formation in sponge spicules. FEBS Open Bio 3, 357-362 (2013).

X.H. Wang, H.C. Schröder, V. Grebenjuk, B. Diehl-Seifert, V. Mailänder, R. Steffen, U. Schloßmacher and W.E.G. Müller: The marine sponge-derived inorganic polymers, biosilica and polyphosphate, as morphogenetically active matrices/scaffolds for differentiation of human multipotent stromal cells: Potential application in 3D printing and distraction osteogenesis. Mar. Drugs 12, 1131-1147 (2014).

X.H. Wang, H.C. Schröder, Q.L. Feng, B. Diehl-Seifert, V.A. Grebenjuk and W.E.G. Müller: Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 and Ets1. Biochem. Pharmacol. 89, 413-421 (2014).

M. Jarry, C. Lecointre, C. Malleval, L. Desrues, M.T. Schouft, V. Le Joncour, F. Liger, G. Lyvinec, B. Joseph, N. Loaëc, L. Meijer, J. Honnorat, P. Gandolfo and H. Castel: Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. Neuro-Oncology, in revision (2014).

P. Da Silva, L. Bendjeddou and L. Meijer: Recherche de substances naturelles à activité thérapeutique: George R. Pettit (1929-). Med./Sci., in press (2014).

X. Fant, E. Durieu, G. Chicanne, B. Payrastre, D. Sbrissa, A. Shisheva, E. Limanton, F. Carreaux, J.P. Bazureau and L. Meijer: Cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases Leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer’s disease. Mol. Pharmacol. 85, 441-450 (2014).

E. Deau, Y. Loidreau, P. Marchand, M.-R. Nourrisson, N. Loaëc, L. Meijer, V. Levacher, and T. Besson: Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr Kinases. Bioorg. Med. Chem. Lett. 23, 6784-6788 (2013).

K. Yoshida, R. Itoyama, M. Yamahira, J. Tanaka, N. Loaëc, O. Lozach, E. Durieu, T. Fukuda, F. Ishibashi, L. Meijer and M. Iwao: Synthesis, resolution and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarin Ns: unique effects of the axial chirality on the selectivity inhibition of protein kinases. J. Med. Chem. 56, 7289-7301 (2013).

C. Bruyère and L. Meijer: Targeting cyclin-dependent kinases in anti-neoplastic therapy. "Cell Cycle, Differentiation and Disease” issue. Curr. Opinion Cell Biol. 25, 772-779 (2013).

R. Teta, G. Della Sala, B. Renga, A. Mangoni, S. Fiorucci, V. Costantino: Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator. Marine Drugs 10, 1383-1390 (2012).

V. Costantino, G. Della Sala, A. Mangoni, C. Perinu, R. Teta: Blurring the Boundary between Bio- and Geohopanoids: Plakohopanoid, a C32 Biohopanoid Ester from Plakortis cf. lita. Eur. J. Org. Chem. 5171-5176 (2012).

M. Menna, A. Aiello, F. D'Aniello, C. Imperatore, P. Luciano, R. Vitalone, C. Irace, R. Santamaria: Conithiaquinones A and B, Tetracyclic Cytotoxic Meroterpenes from the Mediterranean Ascidian Aplidium conicum. Eur. J. Org. Chem. 3241-3246 (2013).

M. Menna, C. Imperatore, F. D'Aniello, A.: Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications. Marine Drugs 11, 1602-1643 (2013).

A. M. S. Mayer, A. D. Rodriguez, O. Taglialatela-Scafati, N. Fusetani: Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar. Drugs 11, 2510-2573 (2013).

A. Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga, S. Fiorucci, O. Taglialatela-Scafati: Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei. Bioorg. Med. Chem. 21, 5332-5338 (2013).

A. Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga, S. Fiorucci, O. Taglialatela-Scafati: New Tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei. Beilstein J. Org. Chem. 9, 1643-1651 (2013).

G. Della Sala, T. Hochmuth, V. Costantino, R. Teta, W. Gerwick, L. Gerwick, J. Piel, A. Mangoni: Polyketide Genes in the Marine Sponge Plakortis simplex: a New Group of Mono-Modular Type-I Polyketide Synthases from Sponge Symbionts. Environ. Microbiol. Rep. 5, 809–818 (2013).

R. Teta, E. Irollo, G. Della Sala, G. Pirozzi, A. Mangoni, V. Costantino: Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research. Marine Drugs 11, 4451-4463 (2013).

G. Chianese, F. Scala, B. Calcinai, C. Cerrano, H. A. Dien, M. Kaiser, D. Tasdemir, O. Taglialatela-Scafati: Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity. Marine Drugs 11, 3297-3308 (2013).

M. Persico, S. Parapini, G. Chianese, C. Fattorusso, M. Lombardo, L. Petrizza, A. Quintavalla, F. Rondinelli, N. Basilico, D. Taramelli, C. Trombini, E. Fattorusso, O. Taglialatela-Scafati: Further optimization of plakortin pharmacophore: Structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity. Eur. J. Med. Chem. 70, 875-886 (2013).

M. Menna: Important Classes of Bioactive Alkaloids from Marine Ascidians: Structures, Isolation and Bioactivity. Current topics in medicinal chemistry 14, 207-223 (2014).  

M. Lombardo, D. P. Sonawane, A. Quintavalla, C. Trombini, D. D. Dhavale, D. Taramelli, Y. Corbett, F. Rondinelli, C. Fattorusso, M. Persico, O. Taglialatela-Scafati: Optimized Synthesis and Antimalarial Activity of New 1,2-Dioxane-4-Carboxamides. Eur. J. Org. Chem. 1607-1614 (2014).

M.C. Wilson, T. Mori, C. Rückert, A.R. Uria, M.J. Helf, K. Takada, C. Gernert, U.A.E. Steffens, N. Heycke, S. Schmitt, C. Rinke, E.J.N. Helfrich, A.O. Brachmann, C. Gurgui, T. Wakimoto, M. Kracht, M. Crüsemann, U. Hentschel, I. Abe, S. Matsunaga, J. Kalinowski, H. Takeyama, J. Piel: An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62 (2014).

P. Pöplau, S. Frank. B.I. Morinaka, J. Piel: An enzymatic domain for the formation of cyclic ethers in complex polyketides. Angew. Chem. Int. Ed. Eng. 52, 13215-13218 (2013).

R. Ueoka, A.R. Uria, S. Reiter, T. Mori, P. Karbaum, E.E. Peters, E.J.N. Helfrich, B.I. Morinaka, M. Gugger, H. Takeyama, S. Matsunaga, J. Piel: Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms. Nat. Chem. Biol. 11, 705-712 (2015).

X.H. Wang, H.C. Schröder, U. Schlossmacher, M. Neufurth, Q.L. Feng, B. Diehl-Seifert and W.E.G. Müller: Modulation of the initial mineralization process of SaOS-2 cells by carbonic anhydrase activators and polyphosphate. Calcif. Tissue Int. 94, 495-509 (2014).

X.H. Wang, H.C. Schröder and W.E.G. Müller: Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone. Beilstein J. Nanotechnol. 5, 610-621 (2014).

W.E.G. Müller, T. Link, H.C. Schröder, M. Korzhev, M. Neufurth, D. Brandt and X.H. Wang: Dissection of the structure-forming from the structure-guiding activity of silicatein: a biomimetic molecular approach to print optical fibers. J. Mater. Chem. B 2, 5368-5377 (2014).

M. Neufurth, X.H. Wang, H.C. Schröder, Q.L. Feng, B. Diehl-Seifert, T. Ziebart, R. Steffen, S.F. Wang and W.E.G. Müller: Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells. Biomaterials 35, 8810-8819 (2014).

W.E.G. Müller, E. Tolba, H.C. Schröder, B. Diehl-Seifert, T. Link and X.H. Wang: Biosilica-loaded poly(ε-caprolactone) nanofibers mats provide a morphogenetically active surface scaffold for the growth and mineralization of SaOS-2 cells. Biotechnol. J. 9, 1312-1321 (2014).

X.H. Wang, E. Tolba, H.C. Schröder, M. Neufurth, Q.L. Feng, B. Diehl-Seifert and W.E.G. Müller: Effect of bioglass on growth and biomineralization of SaOS-2 in hydrogel after 3D cell bioprinting. PLoS ONE 9, e112497 (2014).

S.F. Wang, X.H. Wang, F.G. Draenert, O. Albert, H.C. Schröder, V. Mailänder, G. Mitov and W.E.G. Müller: Bioactive and biodegradable silica biomaterial for bone regeneration. Bone 67C, 292-304 (2014).

W.E.G. Müller, E. Tolba, H.C. Schröder, M. Neufurth, S.F. Wang, T. Link, B. Al-Nawas and X.H. Wang: A new printable and durable N,O-carboxymethyl chitosan-Ca2+-polyphosphate complex with morphogenetic activity. J. Mater. Chem. B 3, 1722-1730 (2015).

W.E.G. Müller, T. Link, Q. Li, H.C. Schröder, R. Batel, M. BlaĹžina, V.A. Grebenjuk and X.H. Wang: A novel TiO2-assisted magnetic nanoparticle separator for treatment and inactivation of bacterial contaminants in aquatic systems. RSC Adv. 4, 48267-48275 (2014).

Q. Li, X.H. Wang, M. Korzhev, H.C. Schröder, T. Link, M.N. Tahir, B. Diehl-Seifert and W.E.G. Müller: Potential biological role of laccase from the sponge Suberites domuncula as an antibacterial defense component. Biochem. Biophys. Acta 1850, 118-128 (2014).

X.H. Wang, H.C. Schröder and W.E.G. Müller. Enzymatically synthesized inorganic polymers as morphogenetically active bone scaffolds: application in regenerative medicine. Int. Rev. Cell. Mol. Biol. 313, 27-77 (2014).

W.E.G. Müller, E. Tolba, H.C. Schröder, S.F. Wang, G. Glaßer, R. Muñoz-Espí, T. Link and X.H. Wang: A new polyphosphate calcium material with morphogenetic activity. Materials Lett. 148, 163-166 (2015).

W.E.G. Müller, E. Tolba, Q.L. Feng, H.C. Schröder, J.S Markl, M. Kokkinopoulou and X.H. Wang: Amorphous Ca2+ polyphosphate nanoparticles regulate the ATP level in bone-like SaOS-2 cells. J. Cell Sci. 128, 2202-2207 (2015).

W.E.G. Müller, E. Tolba, H.C. Schröder, B. Diehl-Seifert and X.H. Wang: Retinol encapsulated into amorphous Ca2+ polyphosphate nanospheres acts synergistically in MC3T3-E1 cells. Eur. J. Pharm. Biopharm. 93, 214-223 (2015).

W.E.G. Müller, M. Neufurth, J. Huang, K. Wang, Q.L. Feng, H.C. Schröder, B. Diehl-Seifert, R. Muñoz-Espí and X.H. Wang: Nonenzymatic transformation of amorphous CaCO3 into calcium phosphate mineral after exposure to sodium phosphate in vitro: Implications for in vivo hydroxyapatite bone formation. ChemBioChem 16, 1323-1332 (2015).

W.E.G. Müller, E. Tolba, H.C. Schröder and X.H. Wang: Polyphosphate: a morphogenetically active implant material serving as metabolic fuel for bone regeneration. Macromolec Biosci. 15, 1182-1197 (2015).

S.S. Ebada, M.H. Linh, A. Longeon , N.J. de Voogd, E. Durieu, L. Meijer, M.-L. Bourguet-Kondracki, A.N. Singab, W.E.G. Müller, P. Proksch: Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa. Nat. Prod. Res. 3, 231-238 (2015).

C. Bauvais, S. Zirah, L. Piette, F. Chaspoul, I. Domart-Coulon, V. Chapon, P. Gallice, S. Rebuffat, T. Pérez, and M.- L. Bourguet-Kondracki: Sponging up metals: Bacteria associated with the marine sponge Spongia officinalis. Mar. Environm. Res. 104, 20-30 (2015).

F. He, L.H. Mai, A. Longeon, B.R. Copp, N.  Loaëc, A. Bescond, L. Meijer and M.-L. Bourguet-Kondracki: Novel adociaquinone derivatives from the Indonesian marine sponge Xestospongia sp. Mar. Drugs 13, 2617-2628 (2015).

A. Fayad, C. Pubill, Sunil Sharma, D. Day and R.J.M. Goss: A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas. EJOC, in press (2015).

H. Gao, S. Gruschow, M. Hutchings, D. Yu, and R. J. M. Goss Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant. RSC Adv. 4, 57267-57270 (2014).

M.A. Beniddir, E. Le Borgne, B.I. Iorga, N. Loaëc, O. Lozach, L. Meijer, K. Awang and M. Litaudon: Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors. J. Nat. Prod. 77, 1117-1122 (2014).

C. Bruyère and L. Meijer: Targeting cyclin-dependent kinases in anti-neoplastic therapy. "Cell Cycle, Differentiation and Disease” issue. Curr. Opinion Cell Biol. 25, 772-779 (2013).

P.P.J. Da Silva, L.Z. Bendjeddou and L. Meijer: Recherche de substances naturelles à activité thérapeutique: George R. Pettit (1929-). Med./Sci. 30, 319-328 (2014).

E. Deau, Y. Loidreau, P. Marchand, M.-R. Nourrisson, N. Loaëc, L. Meijer, V. Levacher and T. Besson: Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr Kinases. Bioorg. Med. Chem. Lett. 23, 6784-6788 (2013).

S.S. Ebada, M.H. Linh, A. Longeon, N.J. de Voogd, E. Durieu, L. Meijer, M.L. Bourguet-Kondracki, A.N. Singab, W.E.G. Müller and P. Proksch: Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa. Nat. Prod. Res. 29, 231-238 (2015).

H. Falke, A. Chaikuad, A. Becker, N. Loaëc, O. Lozach, S.A. Jhaisha, W. Becker, P.G. Jones, L. Preu, K. Baumann, S. Knapp, L. Meijer and C. Kunick: 10-Iodo-11H-indolo[3,2-c]quinolone-6-carboxylic acids are selective inhibitors of DYRK1A. J. Med. Chem. 58, 3131-3143 (2015).

X. Fant, E. Durieu, G. Chicanne, B. Payrastre, D. Sbrissa, A. Shisheva, E. Limanton, F. Carreaux, J.P. Bazureau and L. Meijer: Cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases Leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer’s disease. Mol. Pharmacol. 85, 441-450 (2014).

A. Foucourt, D. Hédou, C. Dubouilh-Benard, L. Désiré, A.-S. Casagrande, B. Leblond, N. Loäec, L. Meijerand and T. Besson: Design and synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, Part I. Molecules 19, 15546-15571 (2014).

F. He, L.H. Mai, A. Longeon, B.R. Copp, N. Loaëc, A. Bescond, L. Meijer and M.-L. Bourguet-Kondracki: Novel adociaquinone derivatives from the Indonesian sponge Xestospongia sp. Marine Drugs 13, 2617-2628 (2015).

S. Houzé, N.-T. Hoang, O. Lozach, J. Le Bras, L. Meijer, H. Galons and L. Demange: Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents. Molecules 19, 15237-15257 (2014).

M. Jarry, C. Lecointre, C. Malleval, L. Desrues, M.T. Schouft, V. Le Joncour, F. Liger, G. Lyvinec, B. Joseph, N. Loaëc, L. Meijer, J. Honnorat. P. Gandolfo and H. Castel: Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. Neuro-Oncology 16, 1484-1498 (2014).

Y. Loidreau, E. Deau, P. Marchand, M.-R. Nourrisson, C. Logé, G. Coadou, N. Loaëc, L. Meijer and B. Besson : Design and molecular modeling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. Eur. J. Med. Chem. 92C, 124-134 (2015).

K. Yoshida, R. Itoyama, M. Yamahira, J. Tanaka, N. Loaëc, O. Lozach, E. Durieu, T. Fukuda, F. Ishibashi, L. Meijer and M. Iwao: Synthesis, resolution and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarin Ns: unique effects of the axial chirality on the selectivity inhibition of protein kinases. J. Med. Chem. 56, 7289-7301 (2013).

C. Imperatore, A. Aiello, F. D'Aniello, M. Senese, M. Menna: Alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development. Molecules 19, 20391-20423 (2014).

M. Menna: Important Classes of Bioactive Alkaloids from Marine Ascidians: Structures, Isolation and Bioactivity. Current Topics in Medicinal Chemistry 14, 207-223 (2014).

C. Imperatore, F. D'Aniello, A. Aiello, M. Menna, S. Fiorucci, C. D'Amore, V. Sepe: Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor. Marine Drugs 12, 2066-2078 (2014).

G. Chianese, V. Sepe, V. Limongelli, B. Renga, C. D’Amore, A. Zampella, O. Taglialatela-Scafati, S. Fiorucci: Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists. Steroids 83, 80-85 (2014).

G. Chianese, M. Persico, F. Yang, H.-W. Lin, Y.-W. Guo, N. Basilico, S. Parapini, D. Taramelli, O. Taglialatela-Scafati, C. Fattorusso: Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes. Bioorg. Med. Chem. 22, 4572-4580 (2014).

S. Loffredo, R. I. Staiano, F. Granata, V. Costantino, F. Borriello, A. Frattini, A. Mangoni, G. Marone, M. Triggiani: Simplexide Induces CD1d-Dependent Cytokine and Chemokine Production from Human Monocytes. PLoS ONE 9, e111326 (2014).

G. Della Sala, T. Hochmuth, R. Teta, V. Costantino, A. Mangoni: Polyketide Synthases in the Microbiome of the Marine Sponge Plakortis halichondrioides: a Metagenomic update. Mar. Drugs 12, 5425-5440 (2014).

M. Andreoli, M. Persico, A. Kumar, N. Orteca, V. Kumar, A. Pepe, S. Mahalingam, A.E. Alegria, L. Petrella, L. Sevciunaite, A. Camperchioli, M. Mariani, A. Di Dato, E. Novellino, G. Scambia, S.V. Malhotra, C. Ferlini, C. Fattorusso: Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J. Med. Chem. 57, 7916-7932 (2014).

Z.F. Zhou, M. Menna, Y.S. Cai, Y.W. Guo: Polyacetylenes of Marine Origin: Chemistry and Bioactivity. Chem. Rev. 115, 1543-1596 (2015).

G. Esposito, R. Teta, R. Miceli, L. S. Ceccarelli, G. Della Sala, R. Camerlingo, E. Irollo, A. Mangoni, G. Pirozzi, V. Costantino: Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea. Mar. Drugs  13, 444-459 (2015).

M. Persico, L. Petrella, N. Orteca, A. Di Dato, M. Mariani, M. Andreoli, M. De Donato, G. Scambia, E. Novellino, C. Ferlini, C. Fattorusso: GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1. Eur. J. Med. Chem. 91, 132-144 (2015).

M. Persico, A. Di Dato, N. Orteca, C. Fattorusso, E. Novellino, M. Andreoli, C. Ferlini: From protein communication to drug discovery. Curr. Top Med. Chem., 15 (2015)

W.E.G. Müller, E. Tolba, B. Dorweiler, H.C. Schröder, B. Diehl-Seifert and X.H. Wang: Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochem. Biophys. Rep. 3, 150-160 (2015).

X.H. Wang, S.F. Wang, F. He, E. Tolba, H.C. Schröder, B. Diehl-Seifert and W.E.G. Müller: Polyphosphate a bioactive and biodegradable implant material: induction of bone regeneration in rats. Adv. Engin. Mater., in press (2015). DOI: 10.1002/adem.201600057.

W.E.G. Müller, H.C. Schröder, E. Tolba, B. Diehl-Seifert and X.H. Wang: Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions. FEBS J. 283, 74-87 (2016).

X.H. Wang, H.C. Schröder and W.E.G. Müller: Polyphosphate a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications. Biotechnol. J. 11, 11-30 (2016).

W.E.G. Müller, M. Neufurth, E. Tolba, S.F. Wang, W. Geurtsen, Q.L. Feng, H.C. Schröder and X.H. Wang: A biomimetic approach to ameliorate dental hypersensitivity by amorphous polyphosphate microparticles. Dent Mater. 32, 775-783 (2016).

W.E.G. Müller, E. Tolba, H.C. Schröder, S.F. Wang, G. Glasser, B. Diehl-Seifert and X.H. Wang: Biologizing titanium alloy implant material with morphogenetically active polyphosphate. RSC Adv. 5, 75465–75473 (2015).

W.E.G. Müller, E. Tolba, H.C. Schröder, R. Muñoz-Espí, B. Diehl-Seifert and X.H. Wang: Amorphous polyphosphate-hydroxyapatite: A morphogenetically active substrate for bone-related SaOS-2 cells in vitro. Acta Biomater. 31, 358-367 (2016).

E. Tolba, W.E.G. Müller, B.M. Abd El-Hady, M. Neufurth, F. Wurm, S.F. Wang, H.C. Schröder and X.H. Wang: High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite. J. Mater. Chem. B 4, 376-386 (2016).

W.E.G. Müller, M. Neufurth, S.F. Wang, E. Tolba, H.C. Schröder and X.H. Wang: Morphogenetically active scaffold for osteochondral repair (polyphosphate/alginate/N,O- carboxymethyl chitosan. Eur. Cell Mater. 31, 174-190 (2016).

X.H. Wang, M. Ackermann, S .F. Wang, E. Tolba, M. Neufurth, Q.L. Feng, H.C. Schröder and W.E.G. Müller: Amorphous polyphosphate/amorphous calcium carbonate implant material with enhanced bone healing efficacy in a critical-size defect in rats. Biomed. Mater. 11, 035005 (2016). 

G. Esposito, G. Della Sala, R. Teta, A. Caso, M.L Bourguet-Kondracki, J.R. Pawlik, A. Mangoni, V. Costantino. Chlorinated thiazole containing polyketide-peptides from the Caribbean sponge Smenospongia conulosa: structure elucidation on microgram scale. European Journal of Organic Chemistry. (May 2016).  doi:10.1002/ejoc.201600370

J. Gardères , M.-L. Bourguet-Kondracki , B. Hamer, R. Batel , H. C. Schröder , W. E.G. Müller, Porifera lectins: diversity, physiological roles and biotechnological potential. Mar. Drugs. 13(8), 5059-5101(2015).

J. Gardères , I. Domart-coulon, B. Hamer, R. Batel , W. E.G. Müller and M.-L. Bourguet-Kondracki, Purification and partial characterization of a lectin protein complex, the clathrilectin, from the calcareous sponge Clathrina clathrus. Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology. 200, 17-27 (2016).doi:10.1016/j.cbpb.2016.04.007

G. Esposito, M.-L. Bourguet-Kondracki, A. Longeon, R. Teta, L. Meijer, R. van Soest, A. Mangoni, and V. Costantino, Chloromethylhalicyclamine B, a marine-derived protein kinase CK1δ/ε inhibitor, submitted.

D. Day and R.J.M. Goss: A One-Pot Synthesis of Symmetrical and Unsymmetrical Dipeptide Ureas.  EJOC, 25, 5603-5609 (2015).

H. Gao, S. Gruschow, M. Hutchings, D. Yu, and R. J. M. Goss: Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant. RSC Adv. 4, 57267-57270 (2014).

S.Gruschow, D. Smith, D. Gkotski, R.J.M. Goss: Science of Synthesis, Halogenases (book chapter). Science of Synthesis 313-360 (2014).

D. Smith, S. Ballet, B. U. Maes, T. Willemse and R.J.M. Goss: Simple and scale-able access to 7-halotryptophans, including L-7-iodotryptophan, through a one-pot biotransformation. Orglett. 16, 10, 2622-2625 (2014).

D. Smith, E. Bogosyan, K. Mahoney and R.J.M. Goss: Access to High Value Natural and Unnatural Products through Hyphenating Chemical Synthesis and Biosynthesis. Synthesis 46, 2122-2132 (2014).

 

Book Chapters [all partners]

H.C. Schröder, X.H. Wang, U. Schloßmacher, M. Wiens and W.E.G. Müller: Biogenic inorganic polysilicates (bio-silica): formation and biomedical applications. In: Biomedical inorganic polymers: Bioactivity and applications of natural and synthetic polymeric inorganic molecules (W.E.G. Müller, X.H. Wang and H.C. Schröder, eds.), Springer-Press, Berlin; Prog. Mol. Subcell. Biol. 54, 197-234 (2013).

W.E.G. Müller, H.C. Schröder, Z.J. Shen, Q.L. Feng and X.H. Wang: Inorganic polymers: Morphogenic inorganic biopolymers for rapid prototyping chain. In: Biomedical inorganic polymers: Bioactivity and applications of natural and synthetic polymeric inorganic molecules (W.E.G. Müller, X.H. Wang and H.C. Schröder, eds.), Springer-Press, Berlin; Prog. Mol. Subcell. Biol. 54, 235-259 (2013).

X.H. Wang, H.C. Schröder, U. Schloßmacher and W.E.G. Müller: Inorganic polyphosphates: biologically active biopolymers for biomedical applications. In: Biomedical inorganic polymers: Bioactivity and applications of natural and synthetic polymeric inorganic molecules (W.E.G. Müller, X.H. Wang and H.C. Schröder, eds.), Springer-Press, Berlin; Prog. Mol. Subcell. Biol. 54, 261-294 (2013).

W.E.G. Müller, X.H. Wang and H.C. Schröder (eds.) Biomedical Inorganic Polymers: Bioactivity and Applications of Natural and Synthetic Polymeric Inorganic Molecules. Springer-Press, Berlin, pp. 1-303 (2013).

X.H. Wang, U. Schloßmacher, H.C. Schröder and W.E.G. Müller: A Milestone in biomineralization: From a structural assessment to a genetic concept of mineral formation. Or how the enzyme silicatein forms a solid silica rod. In: Progress in Silicones and Silicone-Modified Materials (Eds.: S.J. Clarson, M.J. Owen, S.D. Smith, M. van Dyke, M. Brook and J. Mabry). ACS Symposium Ser., Vol. 1154, pp. 157-176 (2013).

W.E.G. Müller, O. Albert, H.C. Schröder and X.H. Wang: Bio-inorganic nanomaterials for biomedical applications (bio-silica and polyphosphate). In Handbook of Nanomaterials Properties (B. Bhushan, , D. Luo, S. Schricker, W. Sigmund and S. Zauscher, eds.), Springer Press Berlin Heidelberg, pp. 389-408 (2014)

X.H. Wang, H.C. Schröder and W.E.G. Müller: Enzymatically Synthesized Biosilica. In: Springer Handbook of Marine Biotechnology (S.K. Kim, Ed.), pp. 1265- 1277 (2015).

A. E. Osbourn, G. Carter, and R.J.M. Goss (Eds.) Natural Products: Discourse, Diversity and Design. Wiley-Blackwell (2014). ISBN: 978-1-118-29806-0.

S. Gruschow, D. Smith, D. Gkotski, R.J.M. Goss: Halogenases in synthesis. Science of Synthesis, in press (2014).

A. Aiello, C. Imperatore, F. D'Aniello, M. Menna: Bioactive Alkaloids of Marine Origin: in Alkaloids: Biosynthesis, Biological Roles and Health Benefits, Series: Biochemistry Research Trends, Eduardo Sobarzo-Sánchez Ed. Authors / Editors:  Eduardo Sobarzo-Sánchez, NOVA, e-book (2015).

X.H. Wang, H.C. Schröder and W.E.G. Müller: Properties and applications of biosilica enzymatically synthesized by aquatic/marine sponges. In Functional Marine Biomaterials: Properties and Applications (S.-K. Kim, Ed.). Woodhead Publishing Series in Biomaterials: Number 100, Elesevier, Amsterdam, pp. 33-50 (2015).